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Chemical Structure : XPC-6444
Catalog No.: PC-73070Not For Human Use, Lab Use Only.
XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM).
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XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM).
XPC-6444 displays no significant inhibition against NaV1.1 and NaV1.5 (IC50>10 uM).
XPC-6444 produced potent anticonvulsant activity in mouse seizure models, including a direct current maximal electroshock seizure assay.
| M.Wt | 498.583 | |
| Formula | C22H25F3N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Focken T, et al. J Med Chem. 2019 Sep 17. doi: 10.1021/acs.jmedchem.9b01032.
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