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Chemical Structure : XPC-7224
Catalog No.: PC-21778Not For Human Use, Lab Use Only.
XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel.
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XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel.
XPC-7224 is >100-fold more potent than all other NaV subtypes.
XPC-7224 (500 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons.
NaV1.6 R1626A displays a > 1000-fold drop in potency for XPC-7224.
| M.Wt | 483.61 | |
| Formula | C25H30FN5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.
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