XSY12 | NSD3 degrader | Probechem Biochemicals

Chemical Structure : XSY12

XSY12 (XSY-12)

Catalog No.: PC-28639Not For Human Use, Lab Use Only.

XSY12 is a hydrophobic-tag degrader of the NSD3 PWWP domain that enables cellular NSD3 depletion (DC50=2.21 μM, Dmax=80.2%), promotes proteasome-dependent NSD3 depletion, reduces H3K36 methylation, and induces apoptosis and G2/M arrest in NSD3-dependent models.

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Biological Activity

Physicochemical Properties

M.Wt	546.00
Formula	C32H21ClFN5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-chlorophenyl)-N-(9H-fluoren-9-yl)-3-((5-fluoropyridin-3-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide

References

1. Si-Yu Xiu, et al. J Med Chem. 2026 Aug 13;69(15):18637-18664.

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XSY12 (XSY-12)

Biological Activity

Physicochemical Properties

References

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