Chemical Structure : XYD224
CAS No.:
XYD224
(XYD-224)
Catalog No.: PC-26928Not For Human Use, Lab Use Only.
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells.
XYD224 efficiently induces BRD9 degradation in multiple AML cell lines, including MV4-11, MOLM-13, MOLM-16, Kasumi-1
XYD224 induces BRD9 degradation in a time-, dose-, CRBN-, and proteasome-dependent manner.
XYD224 (10 and 20 mg/kg (i.p.)) achieved tumor growth inhibition (TGI) rates of 70 and 79%, respectively, with a favorable safety profile in the MV4-11 xenograft model.
Physicochemical Properties
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M.Wt
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750.92
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Formula
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C43H51FN6O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((4-(7-((1-(4-(3-acetylindolizin-1-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)-3-fluorophenyl)amino)piperidine-2,6-dione
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References
1. Xin Tang, et al. J Med Chem. 2026 May 27. doi: 10.1021/acs.jmedchem.6c00491.
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