Chemical Structure : Y041-2712
CAS No.:
1008904-65-1
Y041-2712
Catalog No.: PC-24494Not For Human Use, Lab Use Only.
Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins.
Y041-2712 shows favorable CDK8 selectivity when tested against a panel of kinases.
Y041-2712 reduced TGF-β1-induced cell migration in a concentration-dependent manner.
Y041-2712 (5 uM) showed a similar reduction in cell migration in TGF-β1-induced A549 cells.
Y041-2712 reduces EMT protein expression and disrupts TGF-β1 signaling.
Y041-2712 exhibited concentration-dependent inhibition of TGF-β1-induced COL1A1 protein expression in WI-38 cells.
Y041-2712 shows potentially impacting the transcription of IPF related protein expression.
Physicochemical Properties
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M.Wt
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336.39
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Formula
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C20H20N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(4-methoxyphenyl)-1H-pyrazol-3-yl)-5-((2-methylallyl)oxy)phenol
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References
1. Lin TE, et al. Biochem Pharmacol. 2025 Apr 23:116959.
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