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Chemical Structure : Y15
CAS No.: 4506-66-5
Catalog No.: PC-43036Not For Human Use, Lab Use Only.
FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $198 | In stock | |
| 1 g | Get quote |
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FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK.
Y15 does not significantly decrease kinase activity of the other kinases (Pyk2 autophosphorylation).
Y15 directly and specifically decreases Y397-phosphorylation of FAK in vitro, inhibits cancer cell viability in vitro, causes detachment, decreases cell adhesion and blocks tumor growth in vivo.
| M.Wt | 284.0142 | |
| Formula | C6H14Cl4N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 59 mg/mL |
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| Chemical Name/SMILES |
1,2,4,5-Benzenetetramine, hydrochloride (1:4) |
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1. Hochwald SN, et al. Cell Cycle. 2009 Aug;8(15):2435-43.
2. Zheng D, et al. Mol Carcinog. 2010 Feb;49(2):200-9.
3. Beierle EA, et al. Cell Cycle. 2010 Mar 1;9(5):1005-15.
4. Golubovskaya VM, et al. J Med Chem. 2008 Dec 11;51(23):7405-16.
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