Chemical Structure : Y2641
CAS No.:
3092616-03-7
Y2641
(Y-2641)
Catalog No.: PC-25332Not For Human Use, Lab Use Only.
Y2641 is a potent, dual RANKL and TNF-α inhibitor with binding affinity (KD) of 3.984 uM) and 18.59 uM respectively, exhibits potent RANKL-induced osteoclastogenic inhibition with IC50 of 109.1 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Y2641 is a potent, dual RANKL and TNF-α inhibitor with binding affinity (KD) of 3.984 uM) and 18.59 uM respectively, exhibits potent RANKL-induced osteoclastogenic inhibition with IC50 of 109.1 nM.
Y2641 exhibits significant TNF-α/LPS-induced inflammation inhibitory activity in vitro via inhibiting TNF-α related NF-κΒ signaling pathway.
Y2641 simultaneously has cartilage catabolic inhibition and cartilage anabolic promotion in primary chondrocyte.
Y2641 significantly reduces the subchondral bone resorption and cartilage destruction in anterior cruciate ligament transection (ACLT)-induced OA rats.
Physicochemical Properties
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M.Wt
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436.56
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Formula
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C28H28N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(2,6-dimethylphenyl)-1-phenyl-2',3',4',9'-tetrahydrospiro[azetidine-3,1'-pyrido[3,4-b]indole]-3'-carboxamide
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References
1. Shao Z, et al. J Med Chem. 2025 May 22;68(10):10216-10237.
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