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YB-B1

Chemical Structure : YB-B1

CAS No.: 1184980-85-5

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YB-B1 (YB-1/YBX1 inhibitor)

Catalog No.: PC-25207Not For Human Use, Lab Use Only.

YB-B1 is a small molecule Y-box-binding protein 1 (YBX1, YB-1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YB-B1 is a small molecule Y-box-binding protein 1 (YBX1, YB-1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM.
    YB-B1 significantly suppresses proliferation of HEY and OV90 cells with IC50 of 3.5 and 11.9 uM respectively.
    YB-B1 decreases the expression of CCNL2 and YBX1.
    YB-B1 exhibits a synergistic effect with cisplatin, enhances chemotherapy-induced cytotoxicity in ovarian cancer cells and the PDX model.

    Physicochemical Properties

    M.Wt 388.43
    Formula C21H20N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N5-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-2-ylmethyl)-1H-imidazole-4,5-dicarboxamide

    References

    1. Zhang K, et al. J Ovarian Res. 2025 Jul 24;18(1):162.

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