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Chemical Structure : YH12852
Catalog No.: PC-62093Not For Human Use, Lab Use Only.
YH12852 is a potent, highly selective 5-HT4 receptor agonist with pKi of 10.3, exhibits more potent agonistic activity (pEC50=11.4) than both tegaserod and prucalopride.
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YH12852 is a potent, highly selective 5-HT4 receptor agonist with pKi of 10.3, exhibits more potent agonistic activity (pEC50=11.4) than both tegaserod and prucalopride.
YH12852 exhibits high selectivity for the 5-HT4 receptor over other 5-HT receptor subtypes and non-5-HT receptors.
YH12852 significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus.
| M.Wt | 399.46 | |
| Formula | C19H25N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hussain Z, et al. Neurogastroenterol Motil. 2017 Oct;29(10):1-6.
2. Jeong EJ, et al. Br J Pharmacol. 2018 Feb;175(3):485-500.
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