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Chemical Structure : YH239-EE
CAS No.: 1364488-67-4
Catalog No.: PC-42949Not For Human Use, Lab Use Only.
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $105 | In stock | |
| 25 mg | $195 | In stock | |
| 50 mg | $365 | In stock | |
| 250 mg | Get quote |
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YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.
| M.Wt | 504.4056 | |
| Formula | C25H27Cl2N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 55 mg/mL |
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| Chemical Name/SMILES |
1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester |
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1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.
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