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Chemical Structure : YK-3-237
Catalog No.: PC-60825Not For Human Use, Lab Use Only.
A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
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A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53; demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5 uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase; enhances expression of α-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).
| M.Wt | 372.18 | |
| Formula | C19H21BO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yi YW, et al. Oncotarget. 2013 Jul;4(7):984-94.
2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):142-51.
3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15;18(2):971-7.
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