Catalog No.: PC-60825Not For Human Use, Lab Use Only.
YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
YK-3-237 demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5 uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase.
YK-3-237 enhances expression of α-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).
