YL0441 | ΔFOSB inhibitor | Probechem Biochemicals

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Chemical Structure : YL0441

YL0441 (YL-0441)

Catalog No.: PC-25798Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YL0441 is a highly effective inhibitor of AP1 transcription factor ΔFOSB with IC50 of 13.7 uM and 12.3 uM, disrupts ΔFOSB/JUND and ΔFOSB/ΔFOSB binding to DNA, inhibits AP1-transcription factor-mediated expression of the luciferase reporter gene with IC50 of 0.1 uM.
YL0441 efficiently disrupts ΔFOSB binding to genomic DNA in brain in vivo, interferes with ΔFOSB binding to DNA and/or promotes its release from chromatin in dorsal hippocampus of APP mice.

Physicochemical Properties

M.Wt	385.39
Formula	C19H15NO6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-(3-(furan-2-yl)acrylamido)-2-phenoxybenzenesulfonic acid

References

1. McNeme S, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683721.

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YL0441 (YL-0441)

Biological Activity

Physicochemical Properties

References

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