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Chemical Structure : YM-355179
Catalog No.: PC-20725Not For Human Use, Lab Use Only.
YM-355179 is a potent selective, and orally available antagonist of CC chemokine receptor 3 (CCR3) with binding IC50 of 7.6 nM (CCL5).
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YM-355179 is a potent selective, and orally available antagonist of CC chemokine receptor 3 (CCR3) with binding IC50 of 7.6 nM (CCL5).
YM-355179 did not affect the binding of CCL5 to CCR1 or CCR5.
YM-355179 inhibited CCL11-induced, intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation with IC(50) values of 8.0, 24, and 29 nM, respectively.
YM-355179 did not affect any CC chemokine receptor (CCR1, CCR2, CCR4, or CCR5)-mediated Ca(2+) influx signals.
YM-355179 (1 mg/kg, oral) inhibited CCL11-induced shape change of whole blood eosinophils in cynomolgus monkeys.
YM-355179 (1 mg/kg, i.v.) also inhibited eosinophil infiltration into airways of cynomolgus monkeys after segmental bronchoprovocation with CCL11.
| M.Wt | 502.59 | |
| Formula | C29H31FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tatsuaki Morokata, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):244-50.
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