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YM348

Chemical Structure : YM348

CAS No.: 372163-84-3

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YM348 (YM-348)

Catalog No.: PC-27113Not For Human Use, Lab Use Only.

YM348 is a potent, selective and orally active 5-HT2C receptor agonist with Ki of 0.89 nM for cloned human 5-HT(2C) receptor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YM348 is a potent, selective and orally active 5-HT2C receptor agonist with Ki of 0.89 nM for cloned human 5-HT(2C) receptor.
Oral administration of YM348 induced penile erections and hypolocomotion in rats.
YM348 at 0.1, 0.3, 1 and 3 mg/kg significantly reduced food intake in a dose-dependent manner in Zucker rats.
YM348 dose-dependently and significantly increased body temperature in rats.

Physicochemical Properties

M.Wt 243.31
Formula C14H17N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine

References

1. Kimura Y, et al. Eur J Pharmacol. 2004 Jan 1;483(1):37-43.

2. Hayashi A, et al. Brain Res. 2004 Jun 18;1011(2):221-7.

3. Hayashi A, et al. J Pharm Pharmacol. 2004 Dec;56(12):1551-6.

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