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YTHDF2 Inhibitor CK-75

Chemical Structure : YTHDF2 Inhibitor CK-75

CAS No.:

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YTHDF2 Inhibitor CK-75 (CK75)

Catalog No.: PC-24105Not For Human Use, Lab Use Only.

YTHDF2 Inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YTHDF2 inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2.
    CK-75 is inactive against the YTH domains of YTHDF1, YTHDF3, YTHDC1, and YTHDC2.
    CK-75 induced cell cycle changes in K562 with increased arrest at the G0/G1 phase, induced apoptosis and inhibited colony formation, and showed moderate inhibitory activity against cell proliferation.

    Physicochemical Properties

    M.Wt 358.35
    Formula C21H14N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-(2-hydroxy-1-naphthoyl)-1H-pyrazol-1-yl)benzoic acid

    References

    1. Qiu X, et al. JACS Au. 2025 Feb 10;5(2):618-630.

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