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Chemical Structure : Z-590
Catalog No.: PC-35242Not For Human Use, Lab Use Only.
Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.
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Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.
Z-590 significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells.
Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo.
| M.Wt | 376.43 | |
| Formula | C21H16N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang Z, et al. Immunopharmacol Immunotoxicol. 2018 Apr;40(2):149-157.
2. Zhang Y, et al. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144.
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