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Chemical Structure : ZCM-I-1
Catalog No.: PC-49181Not For Human Use, Lab Use Only.
ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site.
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ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site.
ZCM-I-1 dose-dependently suppresses mitoROS production as measured by mitoSOX fluorescence, suppresses the production of mitoROS induced by rotenone.
ZCM-I-1 dose dependently reverses mitochondrial depolarization induced by MPP+, a known complex I inhibitor, in both primary mouse cortical neurons and SHSY5Y cells.
ZCM-I-1 has no effects on mitochondrial membrane potential and the level of ATP in MC65 cells, suggesting no effects on the coupling and bioenergetics of mitochondria.
ZCM-I-1 selectively targets mitochondrial complex I via interactions with the IF site.
ZCM-I-1 selectively modulates the respiration of mitochondrial complex I in in isolated mitochondria from the cerebral cortex of C57BL/6 mic, modulates the maximal rate of ADP stimulated respiration of pyruvate as the complex I substrate, but not with succinate as the complex II substrate.
ZCM-I-1 (50 mg/kg, oral gavage, 5 times/week) exhibits selective modulation on the respiration in in vivo using transgenic AD mice since mitochondrial dysfunction.
| M.Wt | 380.444 | |
| Formula | C22H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jakob C Green, et al. J Med Chem. 2020 Oct 22;63(20):11819-11830.
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