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Chemical Structure : ZINC40099027
Catalog No.: PC-73097Not For Human Use, Lab Use Only.
ZINC40099027 is a specific focal adhesion kinase (FAK) activator, actually activates FAK at concentrations as low as 10 nM.
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ZINC40099027 is a specific focal adhesion kinase (FAK) activator, actually activates FAK at concentrations as low as 10 nM.
ZINC40099027 (10–1000 nM) dose-dependently activated FAK phosphorylation, without activating Pyk2-Tyr-402 or Src-Tyr-419.
ZINC40099027 (10 nM) increased FAK-Tyr 397 phosphorylation by 12.9%, 19.1%, 31.1% at 1hr, 6hr, 24hr respectively, in treated migrating Caco-2 cells.
ZINC40099027 stimulates Caco-2 cell monolayer wound closure.
ZINC40099027 dose-dependently increased FAK-Tyr-397 phosphorylation with Emax 36.0% in Caco-2 cells.
ZINC40099027 promotes intestinal mucosal healing in a murine ischemic ulcer model, promotes the healing of indomethacin-induced small intestine injury in mice and does not affect murine kidney and liver morphology.
| M.Wt | 449.47 | |
| Formula | C23H25F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Q, et al. Sci Rep. 2019 Oct 11;9(1):14669.
2. Rashmi, et al. Pharmacol Res Perspect. 2021 Apr;9(2):e00737.
3. Wang Q, et al. ACS Med Chem Lett. 2021 Feb 16;12(3):356-364.
4. Oncel S, et al. Cells. 2021 Apr 15;10(4):908.
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