Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ZL0580
CAS No.: 2377151-10-3
Catalog No.: PC-73041Not For Human Use, Lab Use Only.
ZL0580 (ZL-0580) is a small molecule that induces epigenetic suppression of HIV via BRD4, suppresses PMA-induced HIV activation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $798 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ZL0580 (ZL-0580) is a small molecule that induces epigenetic suppression of HIV via BRD4, suppresses PMA-induced HIV activation.
ZL0580 induces epigenetic reprogramming of HIV LTR in J-Lat cells, suppresses HIV in in vitro HIV-infected human CD4+ T cells, did not significantly alter HIV DNA levels, but reduced HIV transcription in PBMCs.
ZL0580 suppresses HIV transcription ex vivo in PBMCs of viremic HIV-infected participants.
ZL0580 more selectively binds to the BRD4 BD1 domain (IC50=163 nM) instead of BD2 (IC50=1071 nM).
ZL0580 also displays approximately 6- to 11-fold selectivity for BRD4 over other BET proteins (IC50 ranged from approximately 0.9 to 1.9 μM) as well as over a non-BET BD protein, CBP (IC50 >10 uM).
ZL0580 inhibits Tat transactivation and key factors in HIV transcription elongation.
| M.Wt | 532.538 | |
| Formula | C25H23F3N4O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-N-phenyl-1-((4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)sulfonyl)pyrrolidine-2-carboxamide |
|
1. Niu Q, et al. J Clin Invest. 2019 Jul 22;129(8):3361-3373.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
