ZM145 (pNPS145)

Chemical Structure : ZM145

Catalog No.: PC-21995Not For Human Use, Lab Use Only.

ZM145 (pNPS145) is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 2.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication.

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Biological Activity

ZM145 (pNPS145) is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 2.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication.

Physicochemical Properties

M.Wt	361.42
Formula	C20H15N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(6-Hydroxy-1H-indol-3-yl)thiazol-4-yl)-2-methyl-1H-indol-5-ol

References

1. Wu SY, et al. Mol Cell. 2024 Jan 18;84(2):202-220.e15.

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ZM145 (pNPS145)

Biological Activity

Physicochemical Properties

References

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