| Cat. No. |
Product Name |
Information |
| PC-21995 |
ZM145
pBRD4 inhibitor
|
ZM145 (pNPS145) is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 2.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication. |
| PC-21994 |
pNPS90
pBRD4 inhibitor
|
pNPS90 is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 1.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication. |
| PC-21993 |
pNPS14
pBRD4 inhibitor
|
pNPS14 is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 3.39 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication. |
| PC-62478 |
BILH-434
HPV E2 protein inhibitor
|
BILH-434 is a potent HPV11 E1/E2/DNA complex inhibitor that binds to the transactivation domain (TAD) of E2 protein with a Kd of 40 nM, has an IC50 of 180 nM in the E1-E2-ori complex formation assay.. |
| PC-60055 |
Teslexivir
HPV inhibitor
|
Teslexivir (BTA-074, AP611074) is a first-in-class, small molecule protein-protein inhibitor of the interaction between the E1 and E2 proteins of HPV types 6 and 11. |
| PC-25396 |
KTI-240
HPV16 E6 inhibitor
|
KTI-240 is a small molecule inhibitor that covalently bind to cysteine-51 (Cys-51) in HPV16 E6, specifically inhibit HPV16 E6 mediate p53 degradation with EC50 of 2.3 uM in RPE-1 cells. |
| PC-25395 |
KTI-218
HPV16 E6 inhibitor
|
KTI-218 is a small molecule inhibitor that covalently bind to cysteine-51 (Cys-51) in HPV16 E6, specifically inhibit HPV16 E6 mediate p53 degradation with EC50 of 4.2 uM in RPE-1 cells. |
