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Chemical Structure : ZM 336372
CAS No.: 208260-29-1
Catalog No.: PC-43507Not For Human Use, Lab Use Only.
ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 100 mg | $448 | In stock | |
| 500 mg | Get quote |
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ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2.
ZM 336372 suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells, with marked induction of the cell cycle inhibitors p21 and p18.
ZM 336372 blocks cellular proliferation and suppresses NE vasoactive peptide production in pheochromocytoma cells.
| M.Wt | 389.45 | |
| Formula | C23H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]- |
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1. Hall-Jackson CA, et al. Chem Biol. 1999 Aug;6(8):559-68.
2. Van Gompel JJ, et al. Mol Cancer Ther. 2005 Jun;4(6):910-7.
3. Kappes A, et al. J Surg Res. 2006 Jun 1;133(1):42-5.
4. Kunnimalaiyaan M, et al. Surgery. 2007 Dec;142(6):959-64; discussion 959-64.
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