Catalog No.: PC-22756Not For Human Use, Lab Use Only.
ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay.
ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay.
ZW-1226 is 16 times more potent than the known MRP1 inhibitor MK-571 in vesicular transport assay.
ZW-1226 shows good selectivity for MRP1 over other major ABC transporters, including P-gp, BCRP, MRP2 and MRP3.
ZW-1226 effectively reversed MRP1-mediated drug resistance to TOP2 poisons etoposide and doxorubicin in H69AR cells.
ZW-1226 exhibited high tissue to plasma partitioning in mice without altering etoposide distribution to normal tissues.
