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Chemical Structure : ZY-444
Catalog No.: PC-47056Not For Human Use, Lab Use Only.
ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway.
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ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway.
ZY‐444 displayed potent efficacy against cancer proliferation and invasion but much less toxicity to normal cells.
ZY‐444 selectively inhibited invasive breast cancer (BCA) proliferation (IC90=5 uM), migration, and invasion.
ZY‐444 suppressed BCA growth, metastasis, and lung colonization in vivo.
ZY‐444 is an inhibitor of pyruvate carboxylase (PC) by binding to and inhibiting its enzymatic activity without influencing PC expression.
ZY‐444 inhibited the Wnt signaling pathway in MDA‐MB‐231 cells.
| M.Wt | 444.597 | |
| Formula | C26H28N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qingxiang Lin, et al. Adv Sci (Weinh). 2020 Mar 12;7(9):1903483.
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