Chemical Structure : ZYDG2
CAS No.:
1800325-85-2
ZYDG2
Catalog No.: PC-24515Not For Human Use, Lab Use Only.
ZYDG2 is a potent and selective agonist for GPR40 (FFAR1) with EC50 of 41 nM and 17 nM in cell-based functional inositol 1-phosphate-ELISA assay and Ca2+ mobilization assay, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZYDG2 is a potent and selective agonist for GPR40 (FFAR1) with EC50 of 41 nM and 17 nM in cell-based functional inositol 1-phosphate-ELISA assay and Ca2+ mobilization assay, respectively.
ZYDG2 demonstrates dose-dependent improvement in glucose tolerance tests and increased insulin secretion in neonatal streptozotocin Wistar rats.
ZYDG2 significantly increased the glucose infusion rate in a hyperglycemic clamp study and demonstrated antidiabetic efficacy in mice models of type 2 diabetes mellitus.
ZYDG2 is a highly promising and unequivocally safe therapeutic candidate for the treatment of type 2 diabetes.
Physicochemical Properties
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M.Wt
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405.49
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Formula
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C25H27NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3S)-3-(4-((3-((6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)methyl)benzyl)oxy)phenyl)hex-4-ynoic acid
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References
1. Jain MR, et al. J Pharmacol Exp Ther. 2025 Mar 6;392(4):103534.
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