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Chemical Structure : Zosuquidar trihydrochloride
CAS No.: 167465-36-3
Catalog No.: PC-45836Not For Human Use, Lab Use Only.
Zosuquidar trihydrochloride (LY-335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Zosuquidar trihydrochloride (LY-335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Zosuquidar trihydrochloride (LY-335979) fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM.
Zosuquidar trihydrochloride (LY-335979) enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.
| M.Wt | 636.9871 | |
| Formula | C32H34Cl3F2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Piperazineethanol, 4-[(1a.alpha.,6.alpha.,10b.alpha.)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[(5-quinolinyloxy)methyl]-, hydrochloride (1:3), (.alpha.R)- |
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1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.
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