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Chemical Structure : biBET
Catalog No.: PC-62224Not For Human Use, Lab Use Only.
biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively.
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biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively.
biBET exhibts very high cellular potency for BRD4 binding and pharmacological responses such as disruption of BRD4-mediator complex subunit 1 foci with an EC50 of 100 pM.
biBET is an useful BET/BRD4 chemical probe.
| M.Wt | 530.593 | |
| Formula | C26H30N10O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Waring MJ, et al. Nat Chem Biol. 2016 Dec;12(12):1097-1104.
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