Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-ADCs and PROTACs-PROTAC-dBAZ2
dBAZ2

Chemical Structure : dBAZ2

CAS No.: 3104449-57-9

dBAZ2

Catalog No.: PC-27854Not For Human Use, Lab Use Only.

dBAZ2 is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2A/B, selectively degrades BAZ2A and BAZ2B with DC50 of 180 nM and 250 nM, and Dmax ≥ 97% in PC3 cells.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dBAZ2 is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2A/B, selectively degrades BAZ2A and BAZ2B with DC50 of 180 nM and 250 nM, and Dmax ≥ 97% in PC3 cells.

Physicochemical Properties

M.Wt 1030.30
Formula C54H64FN11O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-1-((R)-3-((((1r,4R)-4-(((5-(4-cyanophenyl)-4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-2-yl)methoxy)methyl)cyclohexyl)methyl)thio)-2-(1-fluorocyclopropane-1-carboxamido)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Palaferri L, et al. ACS Med Chem Lett. 2025 Jan 7;16(2):234-240.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: