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dBRD9

Chemical Structure : dBRD9

CAS No.: 2170679-45-3

dBRD9 (dBRD 9)

Catalog No.: PC-60126Not For Human Use, Lab Use Only.

dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.
dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.
dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.
dBRD9 exhibits antiproliferative effects in human AML cell lines.

Physicochemical Properties

M.Wt 783.839
Formula C40H45N7O10
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide

References

1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.

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