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Chemical Structure : dBRD9 dihydrochloride
CAS No.: 2341840-98-8
Catalog No.: PC-38462Not For Human Use, Lab Use Only.
dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | $958 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.
dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.
dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.
dBRD9 exhibits antiproliferative effects in human AML cell lines.
| M.Wt | 856.755 | |
| Formula | C40H47Cl2N7O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride |
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1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.
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