dGPX4 | GPX4 PROTAC | Probechem Biochemicals

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Chemical Structure : dGPX4

dGPX4 (GPX4 PROTAC)

Catalog No.: PC-26132Not For Human Use, Lab Use Only.

dGPX4 is a potent GPX4 PROTAC degrader, depletes GPX4 via proteasomal protein degradation, induces cell-selective ferroptosis by targeting cancer cell microenvironment.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dGPX4 is a potent GPX4 PROTAC degrader, depletes GPX4 via proteasomal protein degradation, induces cell-selective ferroptosis by targeting cancer cell microenvironment.

Physicochemical Properties

M.Wt	975.90
Formula	C46H48Cl2N8O10S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(3-chloro-4-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide

References

1. Tianli Luo, et al. Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202206277.

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