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Chemical Structure : eIF4A3-IN-2
Catalog No.: PC-62424Not For Human Use, Lab Use Only.
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.
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eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases; suppresses the helicase activity of eIF4A3 in an ATPase-dependent manner; targets the exon junction complex (EJC) and suppresses monsense-mediated mRNA decay.
| M.Wt | 602.711 | |
| Formula | C25H19Br2ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Iwatani-Yoshihara M, et al. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.
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