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Chemical Structure : eIF4A3 inhibitor 53a
Catalog No.: PC-61019Not For Human Use, Lab Use Only.
eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM.
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eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM; displays no activity against eIF4A1, eIF4A2, DHX29 and BRR2 ATPase (IC50>100 uM); binds to a non-ATP binding site of eIF4A3, exhibits cellular nonsense-mediated RNA decay (NMD) inhibitory activity and represents a novel molecular probe for further study of eIF4A3, the exon junction complex (EJC) and NMD.
| M.Wt | 588.89 | |
| Formula | C29H23BrClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ito M, et al. J Med Chem. 2017 Apr 27;60(8):3335-3351.
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