Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : iCDM-34
Catalog No.: PC-21584Not For Human Use, Lab Use Only.
iCDM-34 is a small molecule inhibitor with anti-HCV and anti-HBV activities, suppresses HBV DNA and acts as an aryl hydrocarbon receptor (AhR) agonist.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
iCDM-34 is a small molecule inhibitor with anti-HCV and anti-HBV activities, suppresses HBV DNA and acts as an aryl hydrocarbon receptor (AhR) agonist.
iCDM-34 suppresses cellular HBV DNA levels with IC50 of 19.7 uM.
iCDM-34 (30 uM) inhibits medium HBV DNA, HBsAg, and HBeAg with showing a additive effect with entecavir (ETV) in primary cultured human hepatocytes.
iCDM-34 alone does not reduce HBV DNA in the liver, but the combination of iCDM-34 and ETV drastically suppresses the amount of HBV DNA in the liver compared with ETV alone.
iCDM-34 does not induce IFN signaling pathway and induces different characteristic signal pathways compared to CDM-3008 (Cat# PC-21583).
iCDM-34 induces AhR signaling, inhibits phosphorylation of SAMHD1 mediated by CDK1/2, suppresses CDK1/2 mRNA expression.
| M.Wt | 391.19 | |
| Formula | C14H11BrN6O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yutaka Furutani, et al. Cell Death Discov. 2023 Dec 22;9(1):467.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
