Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : iNUB
Catalog No.: PC-60552Not For Human Use, Lab Use Only.
iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.
iNUB binds to NEMO UBAN (ubiquitin binding domain (UBAN)) and competes for interaction with methionine-1-linked linear ubiquitin chains.
iNUB inhibits UBAN-dependent NF-κB activation upon TNFα and TCR/CD28 stimulation, shows selective toxicity to IKK/NF-κB dependent ABC-DLBCL
| M.Wt | 384.387 | |
| Formula | C24H16O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Vincendeau M, et al. Sci Rep. 2016 Jan 7;6:18934.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
