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Chemical Structure : mitoNEET Ligand-1
CAS No.: 188532-26-5
Catalog No.: PC-38243Not For Human Use, Lab Use Only.
mitoNEET Ligand-1 (NL-1) is a small molecule ligand of mitoNEET, a protein that regulate the oxidative capacity of the mitochondria.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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mitoNEET Ligand-1 (NL-1) is a small molecule ligand of mitoNEET, a protein that regulate the oxidative capacity of the mitochondria.
mitoNEET is a viable target for the design and synthesis of novel therapeutic agents aimed at altering mitochondrial function.
NL-1 uncoupled isolated mitochondrial complex I respiration with an IC50 of 2.4 μM and inhibited state III respiration up to 45%, protected the human neuronal cell line SH-SY5Y against rotenone induced cell death.
NL-1 reduced expression of mRNA encoding pro-inflammatory cytokines IL-1β, IL-6, and TNFα, and of mRNA encoding inflammatory mediators iNOS and COX2 in RAW264.7 cells.
NL-1 also reduced expression of mRNA encoding iNOS and COX2 in the spleen and liver of mice with LPS-induced sepsis in injected mice, attenuated LPS-induced oxidative stress and mitochondrial dysfunction.
| M.Wt | 335.462 | |
| Formula | C18H25NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one |
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1. Logan SJ, et al. Basic Res Cardiol. 2015 Mar;110(2):19.
2. Lee S, et al. Cell Death Dis. 2022 Feb 8;13(2):127.
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