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Chemical Structure : mutant EGFR inhibitor B30
Catalog No.: PC-35261Not For Human Use, Lab Use Only.
mutant EGFR inhibitor B30 is a potent, selective, next-generation EGFR mutants inhibitor with IC50 of 1.1 and 7.2 nM for EGFRL858R and EGFRL858R/T790M/C797S, respectively.
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mutant EGFR inhibitor B30 is a potent, selective, next-generation EGFR mutants inhibitor with IC50 of 1.1 and 7.2 nM for EGFRL858R and EGFRL858R/T790M/C797S, respectively; weakly inhibits WT EGFR and double mutant L858R/T790M with IC50 of 10.4 and 34.0 nM; inhibits HCC827 and H1975 cells growth with IC50 of 44 and 400 nM, respectively, suppresses EGFR phosphorylation in a dose-dependent manner in HCC827 cell line and significantly induce the apoptosis of HCC827 cells.
| M.Wt | 571.705 | |
| Formula | C31H38FN9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang H, et al. Eur J Med Chem. 2018 Mar 25;148:221-237.
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