Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : nTRD22
Catalog No.: PC-73021Not For Human Use, Lab Use Only.
nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.
nTRD22 likely elicits TDP-43 phase separation and TDP-43 degradation by blocking RNA binding.
nTRD22 mitigates motor defects in a Drosophila model of ALS overexpressing TDP-43.
| M.Wt | 413.397 | |
| Formula | C19H22F3N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Mollasalehi N, et al. ACS Chem Biol. 2020 Nov 20;15(11):2854-2859.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
