p53 Y220C activator KG13 | p53 Y220C reactivator

You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-MDM2-p53-p53 Y220C activator KG13

Chemical Structure : p53 Y220C activator KG13

p53 Y220C activator KG13 (p53 Y220C reactivator)

Catalog No.: PC-25659Not For Human Use, Lab Use Only.

p53 Y220C activator KG13 is a allele-specific covalent small molecule that selectively reacts with the mutant cysteine Y220C of p53 (p53 Y220C), rescues wild-type thermal stability and gene activation.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

p53 Y220C activator KG13 is a allele-specific covalent small molecule that selectively reacts with the mutant cysteine Y220C of p53 (p53 Y220C), rescues wild-type thermal stability and gene activation.
KG13 stabilized cellular p53 Y220C and activated target gene expression.
KG13 could generate p53 WT activity specifically in tumor cells harboring the p53 Y220C mutation.

Physicochemical Properties

M.Wt	345.45
Formula	C22H23N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-1-(3-methyl-4-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)prop-2-en-1-one

References

1. Guiley KZ, et al. Cancer Discov. 2023 Jan 9;13(1):56-69.

2. Patent WO2025151449 A1.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com