pNPS90 | pBRD4 inhibitor | Probechem Biochemicals

Chemical Structure : pNPS90

pNPS90 (pNPS-binding compound 90)

Catalog No.: PC-21994Not For Human Use, Lab Use Only.

pNPS90 is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 1.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication.

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Biological Activity

pNPS90 is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 1.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication.

Physicochemical Properties

M.Wt	389.47
Formula	C22H19N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-Methoxy-1H-indol-3-yl)-4-(5-methoxy-2-methyl-1H-indol-3-yl)thiazole

References

1. Wu SY, et al. Mol Cell. 2024 Jan 18;84(2):202-220.e15.

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pNPS90 (pNPS-binding compound 90)

Biological Activity

Physicochemical Properties

References

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