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Chemical Structure : r(GGGGCC)n binder 1a
Catalog No.: PC-61243Not For Human Use, Lab Use Only.
A bioactive, specific small molecule that targets RNA of the expanded repeat (r(GGGGCC)exp) with Kd of 9.7 uM.
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r(GGGGCC)n binder 1a is a bioactive, specific small molecule that targets RNA of the expanded repeat (r(GGGGCC)exp) with Kd of 9.7 uM.
r(GGGGCC)n binder 1a significantly decreases poly(GP) of 10, 18 and 47% at 25, 50 or 100 uM, respectively, in (GGGGCC)66-expressing cells.
r(GGGGCC)n binder 1a significantly inhibits RAN translation and foci formation in cultured cells expressing r(GGGGCC)66 and neurons transdifferentiated from fibroblasts of repeat expansion carriers.
| M.Wt | 374.507 | |
| Formula | C24H28N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Su Z, et al. Neuron. 2014 Sep 3;83(5):1043-50.
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