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Chemical Structure : rTRD01
Catalog No.: PC-73020Not For Human Use, Lab Use Only.
rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.
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rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.
rTRD01 inhibited (GGGGCC)4 interaction for TDP-43 102–269 with IC50 of 150 uM.
rTRD01 improved larval turning in a Drosophila model of amyotrophic lateral sclerosis (ALS).
| M.Wt | 344.39 | |
| Formula | C18H21FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. François-Moutal L, et al. ACS Chem Biol. 2019 Sep 20;14(9):2006-2013.
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