β-actin inhibitor C25

Chemical Structure : β-actin inhibitor C25

Catalog No.: PC-26933Not For Human Use, Lab Use Only.

β-actin inhibitor C25 is potent, selective and covalent inhibitor of beta-actin (β-actin), does not target α- or γ-actin, inhibits β-Actin polymerization to disrupt the actin cytoskeleton and lead to cell death in143B cells (IC50=15 nM), selectively and covalently binds to Cys272 in β-actin.

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Biological Activity

Physicochemical Properties

M.Wt	400.88
Formula	C22H22ClFN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-6-((4-fluorophenyl)amino)phenyl)-N-(2-(tetrahydro-2H-pyran-4-yl)ethyl)propiolamide

References

1. Chen W, et al. J Med Chem. 2026 May 29. doi: 10.1021/acs.jmedchem.6c00299.

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