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Chemical Structure : β2AR-IN-15
Catalog No.: PC-70285Not For Human Use, Lab Use Only.
An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
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An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
| M.Wt | 647.614 | |
| Formula | C34H39BrN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.
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