| Cat. No. |
Product Name |
Information |
| PC-27651 |
ABRL8301
11β-HSD1 inhibitor
|
ABRL8301 is a 2-methoxyestradiol derivative that reduces 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression and increases heme oxygenase-1 (HO-1) levels in fibrosis-relevant cell types, shows anti-fibrotic efficacy, promoting mesenchymal-to-endothelial transition (MEndT) and reducing mesenchymal markers. |
| PC-27071 |
INCB13739
11β-HSD1 inhibitor
|
INCB13739 (INCB-13739) is a potent, selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor with enzymatic IC50 of 3.2 nM, inhibits 11β-HSD1 in PBMCs with IC50 of 1.1 nM. |
| PC-24917 |
ESC1002755
17β-HSD10 inhibitor
|
ESC1002755 is a highly potent 17β-Hydroxysteroid type 10 (17β-HSD10) inhibitor with IC50 of 19 nM in biochemical assays, inhibits cellular 17β-HSD10 activity with EC50 of 28 nM in stable HEK 293 cell line overexpressing 17β-HSD10. |
| PC-24810 |
HEAL-116
3βHSD1 inhibitor
|
HEAL-116 is a potent, selective 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor, shows binding specificity to the substrate-binding pocket of 3βHSD1 and effectively neutralizes the local charge environment. |
| PC-21935 |
ABT-384
11β-HSD1 inhibitor
|
ABT-384 is a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with Ki values of 0.1-2.7 nM against rodent, monkey, and human 11β-HSD1. |
| PC-21934 |
MK-0736
11β-HSD1 inhibitor
|
MK-0736 is a potent, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, shows favourable effect on glucose and lipid metabolism, weight reduction and adipokine levels. |
| PC-35792 |
BMS-823778 free base
11β-HSD1 inhibitor
|
BMS-823778 (BMS823778) freebase is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
| PC-35575 |
11β-HSD1-IN-12
11β-HSD1 inhibitor
|
11β-HSD1-IN-12 is a potent, selective, oral 11β-HSD1 inhibitor (IC50=1.1 nM) with high selectivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors. |
| PC-35574 |
HSD-016
11β-HSD1 inhibitor
|
HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively. |
| PC-35573 |
INU-101
11β-HSD1 inhibitor
|
INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rat, and human 11β-HSD1, respectively. |
| PC-35375 |
ASP3662
11β-HSD1 inhibitor
|
ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
| PC-63215 |
BI 187004
11β-HSD1 inhibitor
|
BI 187004 (VTP-34072) is a novel potent, selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor intended to treat type 2 diabetes mellitus (T2D).. |
