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Cat. No. Product Name CAS No. Information
PC-63390

Serlopitant

860642-69-9 Serlopitant (VPD-737, MK-0594) is a potent, selective substance P/neurokinin 1 (NK1) receptor for treating chronic pruritus.

Alcoholism

Discontinued

PC-43012

Atipamezole

104054-27-5 Antipamezole (MPV-1248) is a potent, specific α2-adrenoceptor antagonist with Ki of 1.6 nM; reverses the effects of the sedative dexmedetomidine and medetomidine as a veterinary drug.

Alcoholism

Phase 1 Discontinued

PC-43011

Atipamezole hydrochloride

104075-48-1 Antipamezole (MPV-1248) is a potent, specific α2-adrenoceptor antagonist with Ki of 1.6 nM; reverses the effects of the sedative dexmedetomidine and medetomidine as a veterinary drug.

Alcoholism

Phase 1 Discontinued

PC-61542

MT-7716

1215859-93-0 A highly potent, brain-penetrating ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50  nM for rat and human ORL1 receptors, respectively; displays a relative selectivity over μ receptor and serotonin transporter; significantly suppresses the activity of spontaneously firing rat suprachiasmatic nucleus neurons at 100 nM; induces a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs, represents an interesting agent for the study of circadian rhythms; MT-7716 dose-dependently decreases GABAergic transmission and effectively blocks the ethanol-induced increase in GABA release at these synapses.

Alcoholism

Phase 1 Discontinued

PC-61541

W-212393

610323-32-5 W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50  nM for rat and human ORL1 receptors, respectively; displays a relative selectivity over μ receptor and serotonin transporter; significantly suppresses the activity of spontaneously firing rat suprachiasmatic nucleus neurons at 100 nM; induces a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs, represents an interesting agent for the study of circadian rhythms; MT-7716 dose-dependently decreases GABAergic transmission and effectively blocks the ethanol-induced increase in GABA release at these synapses.

Alcoholism

Phase 1 Discontinued

PC-61349

CVT-10216

1005334-57-5 A potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM); demonstrates therapeutic potential to reduce excessive drinking and to suppress relapse in abstinent alcoholics; also shows both anxiolytic and antidipsotropic properties in rats; selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats.

Alcoholism

Discontinued

PC-61098

PF-05190457

1334782-79-4 A potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36; displays excellent off-target activity in the CEREP panel at 10 uM with exception of serotonin 5-HT2B (IC50=3.7 uM); demonstrates robust increases in glucose-stimulated insulin secretion in human islets.

Alcoholism

Phase 2 Clinical

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