| Cat. No. |
Product Name |
Information |
| PC-42422 |
Danusertib
Aurora kinases inhibitor
|
Danusertib (PHA-739358) is a potent, ATP-competitive Aurora kinase inhibitor with IC50 of 13,79 and 61 nM for Aurora A, B and C, respectively. |
| PC-42650 |
CYC-116
Aurora A/B inhibitor
|
CYC-116 is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM. |
| PC-42757 |
Alisertib
Aurora A inhibitor
|
Alisertib (MLN8237) is a potent and highly selective inhibitor of Aurora A (AURKA) with IC50 of 1.2 nM. |
| PC-45829 |
AT-9283
Aurora kinases inhibitor
|
AT-9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively. |
| PC-42766 |
ENMD-2076
Multikinase inhibitor
|
ENMD-2076 is a multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2, respectively. |
| PC-42912 |
TAK-901
Multikinase inhibitor
|
TAK-901 is a multikinase inhibitor with IC50 of 21 nM and 15 nM for Aurora A/TPX2 and Aurora B/INCENP respectively. |
| PC-42409 |
Tozasertib
Aurora kinases inhibitor
|
Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively. |
| PC-22152 |
JAB-2485
Aurora A inhibitor
|
JAB-2485 is a potent, highly selective small-molecule Aurora kinase A (AURKA) inhibitor with IC50 of 0.33 nM, with >1500-fold selectivity over AURKB and AURKC. |
| PC-22141 |
DBPR728
Aurora A inhibitor
|
DBPR728 is an oral bioavailable acyl-based prodrug of 6K465, which is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-22139 |
6K465
Aurora A inhibitor
|
6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-21560 |
Reversine
Aurora Kinase inhibitor
|
Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively. |
| PC-21147 |
Ilorasertib
Aurora Kinase inhibitor
|
Ilorasertib (ABT-348) is a potent inhibitor of Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases (Aur B IC50=2 nM, PDGFRβ IC50=3 nM). |
