| Cat. No. |
Product Name |
Information |
| PC-45881 |
BCX-1470
Factor D/C1s inhibitor
|
BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
| PC-21966 |
SB290157 trifluoroacetate
C3aR inhibitor
|
SB290157 (SB 290157) trifluoroacetate is a potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM. |
| PC-21941 |
Compstatin
Complement C3 inhibitor
|
Compstatin is a 13-residue cyclic peptide inhibitor of complement C3, specifically binds to C3 and inhibits complement activation by blocking C3 convertase-mediated cleavage of C3. |
| PC-21531 |
WWGKKYRASKLGLAR
C3aR agonist
|
Peptide WWGKKYRASKLGLAR is a super agonist of complement factor C3aR, 12-15 times more active than natural C3a. |
| PC-21289 |
CMP-1611
C1r inhibitor
|
CMP-1611 is a small molecule inhibitor of protease of the complement classical pathway, C1r, directly inhibits classical pathway-specific complement activation in a dose-dependent manner. |
| PC-21288 |
T-ALZ01
C1r inhibitor
|
T-ALZ01 (CMP-1696) is a small molecule inhibitor of complement component C1r. |
| PC-20646 |
C1s inhibitor (R)-8
C1s inhibitor
|
C1s inhibitor (R)-8 is a potent, selective, orally available, and brain-penetrable C1s inhibitor with IC50 of 36 nM, effectively blocks the classical complement pathway. |
| PC-20173 |
Sepimostat
Multi-protease inhibitor
|
Sepimostat (FUT-187) is a potent multi-protease inhibitor with IC50 of 0.097 uM for trypsin, 0.029 uM for pancreatic kallikrein, 0.61 uM for plasma kallikrein, 0.57uM for plasmin, 2.5 uM for thrombin, 20.4 uM for factor Xa and 6.4 uM for C1r. |
