Cat. No. |
Product Name |
Information |
PC-21047 |
YHJ1039
FLT3 inhibitor
|
YHJ1039 is a broad-spectrum kinase inhibitor, possesses excellent potencies against FLT3 mutants (FLT3 D835Y, IC50=0.41 nM) as well as FAK (IC50=7 nM). |
PC-72759 |
CCT245718
Aurora A/FLT3 inhibitor
|
CCT245718 is a potent, dual Aurora A/FLT3 inhibitor with Kd of 39 nM (FLT3 D835Y) and 170 nM (FLT3 ITD), IC50 of 15 nM (Aurora A). |
PC-72543 |
Marbotinib
FLT3 inhibitor
|
Marbotinib (FLT3i-3, Methanone 16) is a highly potent, specific, next-generation FLT3 inhibitor. |
PC-35270 |
AUZ454
FLT3 inhibitor
|
AUZ454 (AUZ-454, K03861) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase. |
PC-43403 |
Crenolanib
FLT3 inhibitor
|
Crenolanib (CP-868596) is a potent, selective PDGFR/Flt-3 inhibitor with Ki of 3.2, 2.1 and 0.74 nM for wild-type PDGFRα, PDGFRβ and FLT3, respectively. |
PC-43312 |
Quizartinib
FLT3 inhibitor
|
Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively. |
PC-42981 |
G-749
|
Denfivontinib (G-749) is a novel potent, broad-spetrum FLT-3 inhibitor with IC50 of 0.4 and 0.6 nM against wt FLT-3 and FLT3-D835Y mutant, respectively. |
PC-60368 |
FLT3-IN-5e
|
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM. |
PC-42447 |
Tandutinib
|
Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively. |
PC-43033 |
Gilteritinib
FLT3/AXL inhibitor
|
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively). |
PC-21565 |
TSN084
Multikinase inhibitor
|
TSN084 (TSN 084) is a unique small molecule multi-kinase inhibitor of drug-resistant mutations of c-Met, Trks, and Flt3, also inhibits other oncotargets including Axl, DDRs, and CDK8/19. |
PC-21415 |
Danatinib
FLT3 inhibitor
|
Danatinib is a potent and selective FLT3 inhibitor with IC50 of 3 nM, overcomes acquired resistance and shows effective inhibition against FLT3-ITD and/or FLT3-TKD mutations. |