| Cat. No. |
Product Name |
Information |
| PC-21943 |
MRK-898
GABA A modulator
|
MRK-898 is an orally active GABA(A) receptor modulator, binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. |
| PC-21611 |
DS-II-73
GABAAR modualtor
|
DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2. |
| PC-49338 |
EVT-201
GABAA PAM
|
EVT-201 (Dimdazenil, EVT 201) is a partial positive allosteric GABA(A) receptor modulator with potential for the treatment of insomnia. |
| PC-38727 |
SGS742
GABAB antagonist
|
CGP 36742 (SGS-742) is a BBB-penetrant GABAB receptor antagonist, discretely up-regulates GABAB receptor binding sites. |
| PC-38491 |
Imidazenil
GABAA modulator
|
Imidazenil is a partial allosteric modulator of gamma-aminobutyric acid type A receptor (GABAA receptor) with anxiolytic and anticonvulsant effects, inhibits [3H] flumazenil binding to mouse cerebral cortical membranes in vitro with IC50 of 0.9 nM. |
| PC-38382 |
Alogabat
GABAA α5 PAM
|
Alogabat is a GABAA α5 receptor positive allosteric modulator (PAM). |
| PC-73410 |
Cipepofol
GABA potentiator
|
Cipepofol (HSK3486) is a small molecule γ-aminobutyric acid (GABA) receptor potentiator and new sedative-hypnotic agent and a promising intravenous anaesthetic candidate. |
| PC-73213 |
CGP 52432
GABAB antagonist
|
CGP 52432 is a potent, selective GABAB receptor antagonist with IC50 of 85 nM. |
| PC-35484 |
HZ-166
|
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors. |
| PC-35454 |
GR3027
|
GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC. |
| PC-63310 |
MIDD0301
|
MIDD0301 is a potent, positive allosteric, α5β3γ2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17 nM, shows no significant binding at the peripheral GABAAR at 10 uM. |
| PC-63159 |
AZD 3043
|
AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM. |
